is a Colombian professional footballer who plays as a forward for Major League Soccer club Orlando City.

Having started his professional career with Colombian side Deportivo Cali, Muriel joined Udinese. His first two seasons at the club saw him loaned out to Granada and Lecce respectively before returning to the club in 2012, during which year he won the Serie A Best Young Revelation award alongside Stephan El Shaarawy. After scoring 15 league goals in 57 appearances, Muriel joined fellow Serie A side Sampdoria in January 2015. He spent two and a half seasons with the club, scoring 21 goals in 79 league appearances before joining Sevilla in 2017. In January 2019, he was sent back to Italy on loan with Fiorentina. In June 2019, Muriel signed for Atalanta for a reported €18 million. In his first season, he recorded 18 league goals and guided Atalanta to UEFA Champions League qualification for the first time in the club's history. The following season, he finished as the third top goalscorer in the Serie A, behind only Cristiano Ronaldo and Romelu Lukaku. Consequently, Atalanta qualified for a second consecutive Champions League tournament; for his efforts, Muriel was included in the 2020–21 Serie A Team of the Year.

Muriel is currently a Colombian international, having represented his nation at a full international level since 2012. He made his senior debut in June 2012, in a World Cup qualifying match against Ecuador, and scored his first goal the following year, netting against Guatemala. He later took part at the 2015, 2019, and 2021 editions of the Copa América, as well as the 2018 FIFA World Cup.