is a Ghanaian former footballer who played as a fullback. He appeared previously for Feyenoord Academy, Espérance de Tunis, and Columbus Crew and spent time on loan at Asante Kotoko.

Afful came through the youth setup at the Feyenoord Academy, spending his first two professional seasons with the academy's senior team. He then moved on loan to Asante Kotoko, spending two seasons with the Porcupines and winning the Ghana Premier League in 2007–08. After four years of professional football, Afful left Ghana for the first time to join Espérance de Tunis of the Tunisian Ligue Professionnelle 1. He played the next six seasons with Tunis, appearing for the club more than 180 times. Tunis won four league titles during Afful's time there, appeared in three CAF Champions League finals, and won the 2011 CAF Champions League Final; Afful scored the only goal over the two legs. In the summer of 2015, Afful moved to the United States and signed for Columbus, helping the club reach MLS Cup 2015 in his first season.

At the international level, Afful made his Ghanaian debut at the 2008 Africa Cup of Nations, helping Ghana to a third-place finish at that tournament. He appeared for the Black Stars at four more AFCON tournaments, finishing as runners-up in 2010 and 2015. He was called up to Ghana's squad for the 2014 FIFA World Cup, appearing twice during the tournament. Afful captained his nation for the first time in a friendly against Congo on 1 September 2015.