is a Colombian professional footballer who plays as a goalkeeper for Categoría Primera A club Atlético Nacional and the Colombia national team.

Ospina began his career at Atlético Nacional, making his debut with the club in 2005. After achieving two domestic titles with Los Verdolagas, Ospina joined French side Nice. In 2014, he joined Arsenal on a four-year deal. During his time in London, Ospina won three trophies with the club: the FA Cup in 2015 and 2017, as well as the 2017 FA Community Shield. In 2018, Ospina was loaned out to Serie A club Napoli. The following year, Napoli permanently signed Ospina. In 2020, Ospina played a pivotal role in Napoli's conquering of the Coppa Italia. Following unsuccessful negotiations to renew his contract with Napoli, Ospina signed for Saudi Pro League side Al Nassr in 2022. In mid-2024, he returned to his home country, rejoining Atlético Nacional, where he won Copa Colombia for the first time of his career.

Ospina has represented his country at a full international level since 2007. At youth level, Ospina represented Colombia at the 2005 FIFA World Youth Championship. Notably, he was part of the Colombia squads that won gold at the 2005 Bolivarian Games and the 2006 Central American and Caribbean Games. Upon his senior debut against Uruguay, he became the youngest goalkeeper to make an appearance for Colombia. He has since earned 128 caps for his nation, making him his nation's most capped player of all time, appearing at four Copa Américas and two World Cups.