Royal Sporting Club Anderlecht, commonly abbreviated to RSC Anderlecht (Dutch: [ˈɑndərlɛxt] , French: [ɑ̃dɛʁlɛkt] , German: [ˈandɐlɛçt]) or RSCA (Dutch: [ˌɛr.ɛs.seːˈaː, -ˈʔaː], French: [ɛʁ.ɛs.se.ɑ] , German: [ˌɛʁʔɛs.tseːˈʔaː]), is a Belgian professional football club based in Anderlecht, Brussels Capital-Region. Anderlecht plays in the Belgian First Division A and is the most successful Belgian football team in European competitions, with five trophies, as well as in the Belgian domestic league, with 34 championship wins. They have also won nine Belgian Cups and hold the record for most consecutive Belgian championship titles, winning five between the 1963–64 and 1967–68 seasons.

Founded in 1908, the club first reached the highest level in Belgian football in 1921–22 and have been playing in the first division continuously since 1935–36 and in Europe since 1964–65. They won their first major trophy after World War II with a championship win in 1946–47. They never finished outside the top six of the Belgian first division with the exception of 2019–20 (8th) and 2022–23. They are ranked 14th amongst all-time UEFA club competition winners, tenth in the International Federation of Football History & Statistics continental Clubs of the 20th Century European ranking and were 41st in the 2012 UEFA team rankings. In 1986, they achieved their best UEFA ranking with a joint first place with Juventus.

Anderlecht have been playing their matches in the Astrid Park in the municipality of Anderlecht since 1917. Their current stadium was renamed Lotto Park in 2019. Previously it was called Constant Vanden Stock Stadium which was first opened in 1983 to replace the former Emile Versé Stadium. They play in purple and white outfits. They have long-standing rivalries with Club Brugge and Standard Liège.