Unione Calcio Sampdoria, commonly referred to as Sampdoria (Italian pronunciation: [sampˈdɔːrja, sanˈdɔːrja]), is an Italian professional football club based in Genoa, Liguria.

Sampdoria was formed in 1946 from the merger of two existing sports clubs whose roots can be traced back to the 1890s, Sampierdarenese and Andrea Doria. Both the team name and colours reflect this union, the first being a combination of the names, the second taking the form of a unique kit design, predominantly blue (for Andrea Doria) with white, red and black bands (for Sampierdarenese) across the centre of the shirt, hence the nickname blucerchiati (\"blue-circled\").

Sampdoria play at Stadio Luigi Ferraris, capacity 33,205, which they share with Genoa's older club, Genoa CFC. The fierce rivalry between the two teams is commonly known as the Derby della Lanterna, and has been contested in Serie A for most of its history.

Sampdoria have won the Scudetto once in their history, in 1991. The club has also won the Coppa Italia four times, in 1985, 1988, 1989 and 1994, and the Supercoppa Italiana once, in 1991. Their biggest European success came when they won the Cup Winners' Cup in 1990. They also reached the European Cup final in 1992, losing the final 1–0 to Barcelona after extra-time. After drawing 0–0 against Juve Stabia in the 2024–25 Serie B, the club was relegated for the first time in their history to Serie C. However, their relegation was halted as fellow Serie B team Brescia were handed a four-point penalty, causing them to fall into the relegation zone. Sampdoria is now slated to play a relegation play-off with Salernitana. Brescia has appealed the points deduction.