The 2021 Africa Cup of Nations (also referred to as AFCON 2021 or CAN 2021), known as the TotalEnergies 2021 Africa Cup of Nations for sponsorship reasons, was the 33rd edition of the Africa Cup of Nations, the biennial international men's football championship of Africa organised by the Confederation of African Football (CAF). The tournament was hosted by Cameroon, and took place from 9 January to 6 February 2022.

The tournament was originally scheduled to be played in June and July 2021. However, the CAF announced on 15 January 2020 that due to unfavourable climatic conditions during that period, the tournament had been rescheduled to be played between 9 January and 6 February 2021. On 30 June 2020, the CAF moved the tournament's dates for the second time to January 2022 following the effects of the COVID-19 pandemic across the continent, whilst retaining the name 2021 Africa Cup of Nations for sponsorship purposes.

Matches were played in six venues across five cities. Algeria were the defending champions, but were eliminated in the first round after finishing bottom of their group. Senegal won their first AFCON title after defeating Egypt in the final 4–2 on penalties, following a 0–0 draw after extra time.